Laboratoire de Chimie Bactérienne UMR 7283

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Accueil > Recherche > Equipe MIGNOT > Thème

Cell biology of bacterial motility

Our team studies how cells make decisions to assemble multicellular structures. Specifically, we use Myxococcus xanthus a social bacterium which uses collective surface motility to predate and form fruiting bodies in hostile environments. In this model system, we have shown that bacteria move using a novel molecular motor that assembles at the bacterial cell pole to form so-called bacterial focal adhesions complexes. We have also studied how motility is regulated by environmental cues and shown that complex signaling networks converge into the spatial regulation of the motility complex, controlling its spatial assembly at the cell pole. Using single cell and computational approaches, we are now investigating how these regulations translate to the formation of multicellular patterns. The long-term goal is to build a high-resolution model of the cell-cell regulations that underlie the formation of bacterial multicellular structures.