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About LCB

Research at LCB aims at exploring the functions of the prokaryotic cell. Bacterial cells constitute extraordinary tools and model systems to assess cellular laws as well as a testimony of the evolutionary and adaptive richness of life. 

The main specificity of LCB : The fantastic diversity of bacterial models !

At LCB, all teams conduct basic research on various prokaryotic species that have different ecological niches : enterobacteria such as Escherichia coli, Bacillus subtilis, Myxococcus soil bacteria, freshwater and marine cyanobacteria,  marine magneto-bacteria, bacteria of biotechnological or medical interest such as Clostridium cellolyticum, symbiont of plants Sinorhizobium

meliloti, plant pathogenic bacteria such as Xylella fastidiosa, mammalian pathogens as Salmonella enterica and Pseudomonas aeruginosa, and bacteria viruses. Very diverse aspects are explored such as environmental adaptation, metabolism, genetics, evolution, cell motility, cells communities, antibiotic resistance, pathogenesis and biotechnologies. The different facets of research in Microbiology - fundamental, environmental, biotechnologies and pathogenesis - are therefore studied in the laboratory.

The guidelines of LCB research may be resumed as :

- Explore at the molecular level the living systems whose study represents a significant added value to our understanding of how cells do function.

- Acquire new knowledge beyond the areas of expertise of each team. Many collaborations within the laboratory allow the development of new concepts and technologies.

Our research teams are supported by significant investments in common equipment to develop cutting edge technologies (Microscopy, Cytometry and cell sorting, DNA sequencing, Microfluidic, Robotics, Data analysis, Bioinformatics, Biosafety level 2 facility). A specific team is specialised in scientific services to help our research teams and provides help with instruments and data analysis.

Thus, we have developed various tools allowing a multi-scale analysis of the bacterial cell by automating the construction of bacterial mutants’ libraries and by backing the phenotypic analysis with the modern approaches of high-throughput sequencing, FACS, super-resolution microscopy, microfluidics and in-depth image analysis. In these areas, the LCB has international recognition.

Transmission of knowledge is a crucial goal for us, an important part of our activity is dedicated to the training of students, through the contribution of many researchers and teachers to the Fundamental and Integrative Microbiology Master program, which is part of the Doctoral School of Health and Life Sciences of Aix-Marseille University.