Laboratoire de Chimie Bactérienne UMR 7283

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Accueil > Research > DOLLA > Theme

Functional Genomics of Anaerobiosis

Dolla’s team

Our goal is to characterize molecular and cellular factors linked to both Life in the absence of oxygen and response to oxidative stress of anaerobic microorganisms. A multidisciplinary approach is developed, including global techniques, like differential proteomics and transcripts analysis, genetics as well as structure/function/activity relationships studies. Two anaerobic bacteria, the genomes of which have been sequenced and annotated, are used as model organisms : Desulfovibrio vulgaris Hildenborough, a mesophilic sulfate-reducing bacterium and Thermotoga maritima, an hyperthermophilic thiosulfatoreducer.
Through our studies, we want to identify new antioxidative systems, characterize their structure/function relationships under extreme conditions and integrate them in the global mechanisms of cell response to oxidative conditions.