Functional Genomics of Anaerobiosis
Our goal is to characterize molecular and cellular factors linked to both Life in the absence of oxygen and response to oxidative stress of anaerobic microorganisms. A multidisciplinary approach is developed, including global techniques, like differential proteomics and transcripts analysis, genetics as well as structure/function/activity relationships studies. Two anaerobic bacteria, the genomes of which have been sequenced and annotated, are used as model organisms : Desulfovibrio vulgaris Hildenborough, a mesophilic sulfate-reducing bacterium and Thermotoga maritima, an hyperthermophilic thiosulfatoreducer. Through our studies, we want to identify new antioxidative systems, characterize their structure/function relationships under extreme conditions and integrate them in the global mechanisms of cell response to oxidative conditions.
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