Laboratoire de Chimie Bactérienne UMR 7283



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7 mars 2019: 1 événement


  • Séminaire LCB

    Jeudi 7 mars 16:00-17:30 - Jennifer Mahony - University College Cork

    Séminaire LCB : Molecular players involved in lactococcal phage DNA injection

    Résumé : The majority of lactococcal dairy phages recognise and bind to a saccharidic component on the surface of the host cell. Following this initial binding step, the phage transfers its genomic DNA into the cytoplasm of the host where it replicates and ultimately produces progeny phages. While the initial phage binding step has been the subject of intense research scrutiny, the subsequent DNA injection step is much more elusive. Here, we describe the identification of a host-encoded membrane protein that is involved in the DNA injection process of the prototypic lactococcal phage, TP901-1. Furthermore, phage mutants that can bypass “injection negative” derivatives of the host provide insights into phage proteins that are involved in the phage DNA injection process.

    Lieu : Salle Georges Morin

    En savoir plus : Séminaire LCB