Laboratoire de Chimie Bactérienne UMR 7283

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6 juin 2019: 1 événement

séminaire

  • Séminaire LCB

    Jeudi 6 juin 11:30-13:00 - Paramita SARKAR - Equipe ANSALDI

    Séminaire LCB : Enquiry into the bacterial physiology using bacteriophage encoded proteins

    Résumé : The host pathogen arms race between bacteria and its phages provide a unique and exciting ‘looking glass’ to study the molecular mechanisms that underlie various survival as well as evolutionary strategies that bacteria employ. Here a case study is presented where phage encoded bacterial transcription inhibitor protein has been exploited to enquire into the bacterial transcriptional stress -response. The bacterial RNA polymerase (RNAP), which catalyzes transcription, is considered the major mediator of cellular adaptive strategies. But how do bacteria respond if a stress factor directly compromises the activity of the RNAP ? Using a phage-derived small protein, bacterial RNAP activity was specifically perturbed in exponentially growing Escherichia coli. It was revealed that adaptation to conditions that directly disturb bacterial RNAP performance could result in a biphasic growth behavior and thereby confer the ‘adapted’ bacterial cells an enhanced ability to tolerate diverse antibacterial stresses. 

    Lieu : Salle Georges Morin

    En savoir plus : Séminaire LCB

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